Definition of «somatic mutations»

Somatic mutations refer to changes in DNA that occur within body cells, as opposed to reproductive or germ cells. These mutations can happen at any time during an individual's life and are not passed on to their offspring. They often result from errors made when the cell is replicating its genetic material (DNA) or due to exposure to environmental factors such as radiation, chemicals or viruses that cause damage to DNA. These mutations can lead to various health issues including cancer and other diseases.

Sentences with «somatic mutations»

  • The Catalogue of Somatic Mutations in Cancer (COSMIC) are a collection of data produced and developed by the Wellcome Trust Sanger Institute. (horizondiscovery.com)
  • He works primarily on de novo genome assembly, the detection of somatic mutations in cancer and, most recently, the development of algorithms for nanopore - based sequencers. (agbt.org)
  • Just as one can't truly identify somatic mutations in a tumor tissue without a matched normal, it's nearly impossible to distinguish de novo mutations in a patient without sequencing both of his or her parents. (massgenomics.org)
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